• Women's Cancer Research Foundation

New Article Published in the European Journal of Gynaecological Oncology

Our Founder and Chairman, Dr. John P. Micha and our President, Bram Goldstein, PhD were substantial contributors to a Case Report that has been recently published in the European Journal of Gynaecological Oncology.

Neoadjuvant chemotherapy, radical hysterectomy and chemoradiation for stage iva cervical carcinoma

Summary: Despite the efficacy of chemotherapy and radiotherapy in the management of locally advanced cervical carcinoma, the overall survival rates are relatively inauspicious. We recount a case involving a 56-year-old stage IVA cervical cancer patient who underwent neoadjuvant chemotherapy, a type V radical hysterectomy and adjuvant chemoradiation in April 2006.The patient remained in clinical remission for five years until she developed a metastatic pulmonary nodule in her right middle lobe that originated from the primary cervical cancer. Thereafter, the patient was diagnosed with a right metastatic cardiophrenic nodule that responded favorably to chemotherapy. However, in August 2014, she presented with a metastatic posterior cranial fossa tumor from which she ultimately expired; interestingly, radiologic imaging revealed no evidence of an abdominopelvic recurrence. While a radical hysterectomy is often indicated for advanced cervical cancer patients with residual disease or those who fail chemoradiation, perhaps in select cases (e.g., stage IVA disease), initial treatment with neoadjuvant chemotherapy and surgery followed by chemoradiation may improve patient survival.

Key words: Cervical cancer; Radical hysterectomy; Chemoradiation; Outcomes.

To read the full paper please download here.

EJGO Case Study
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About Women’s Cancer Research Foundation The Women’s Cancer Research Foundation (WCRF) is one of Southern California’s and the nation’s most active research organizations for female cancers. We are dedicated to serving the interests of patients, families, and friends affected by women’s cancers. WCRF partners with physician-scientists nationally to make differences in women’s lives by offering hope, strength, and progress.

John Paul Micha, M.D. Chairman, Women’s Cancer Research Foundation

Women’s Cancer Research Foundation (WCRF)

361 Hospital Road, Suite 422

Newport Beach, CA 92663

PH: (949) 642-5165

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Since 1985, the WCRF physicians have been pioneers in clinical research to improve cure rates for women with ovarian, uterine, cervical, and other gynecologic cancers.


WCRF designs, conducts and publishes research on new leading edge medical treatments.

WCRF is not only conducting and publishing original research but is also a clearing house for information about the latest advancements in treating gynecologic cancers for physicians and patients.


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