• Women's Cancer Research Foundation

Human Papillomavirus Infection Determines Prognosis in Cervical Cancer



Clinical research has identified a strong association between the detection of human papillomavirus (HPV) and invasive cervical cancer prognosis, although no studies have corroborated these results with genetic sequencing (genetic sequencing informs scientists about the kind of genetic information that is included in a particular DNA segment).


Researchers suggest that there is strong prognostic value in genetically sequencing tumors with high-risk HPV status.

A recent study was conducted that involved genetic sequencing of 392 of 2,845 invasive cervical cancer cases that were negative for HPV, which led to identification of an additional 169 cases of HPV-positive disease. A 43% reduction in excess mortality was observed in correlation with patients exhibiting high-risk HPV-positive disease compared with HPV-negative disease. The mortality reduction was consistent across cancer stages, histology and patient clinical characteristics.


For patients with cervical cancer, researchers suggest that there is strong prognostic value in genetically sequencing tumors with high-risk HPV status and therefore, consideration should be given to introducing HPV testing of cervical tumors during patients’ routine clinical workup to further elucidate their clinical outcomes.


About Women’s Cancer Research Foundation

The Women’s Cancer Research Foundation (WCRF) is one of the most active research organizations in the nation. We are dedicated to studying and evaluating novel treatments for women afflicted with breast, ovarian, endometrial, and cervical cancers. The WCRF persistently endeavors to make a difference in women’s lives by offering them hope, strength, and progress.


Women’s Cancer Research Foundation (WCRF)


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