• Women's Cancer Research Foundation

Short-term Impact of Surgically Induced Menopause on Cognitive Function and Wellbeing

Short-term impact of surgically induced menopause on cognitive function and wellbeing in women at high risk for ovarian cancer following risk-reducing bilateral salpingo-oophorectomy.


Recently, Chang H, et al. (2020) conducted a study to evaluate the short-term effect of surgically induced menopause (when surgery, rather than the natural aging, causes a woman to undergo menopause) on cognitive function and quality of life in women at high risk for ovarian cancer following a risk-reducing bilateral salpingo-oophorectomy (a surgical procedure comprising the removal of the ovaries and fallopian tubes that is indicated for reducing the risk of developing ovarian cancer in patients with hereditary ovarian cancer syndrome).

The prospective study involved 57 premenopausal women who were at high risk for developing ovarian cancer

The prospective study involved 57 premenopausal women who were at high risk for developing ovarian cancer and was intended to potentially identify changes in cognition following risk-reducing surgery and the impact of receiving subsequent hormone therapy on cognition. The results demonstrated that women who were at high risk of developing ovarian cancer who elected to undergo risk-reducing surgery and were treated with hormone therapy, may also be at risk for cognitive decline within the first 6 months of surgical menopause.

After menopause, women can anticipate greater difficulty with sleeping, a concern which is not alleviated by hormone therapy

Additionally, after menopause, women can anticipate greater difficulty with sleeping, a concern which is not alleviated by hormone therapy. Patients undergoing risk-reducing surgery should consider these issues prior to surgery and have a comprehensive discussion with their physician regarding this matter.


About Women’s Cancer Research Foundation The Women’s Cancer Research Foundation (WCRF) is one of Southern California’s and the nation’s most active research organizations for female cancers. We are dedicated to serving the interests of patients, families, and friends affected by women’s cancers. WCRF partners with physician-scientists nationally to make differences in women’s lives by offering hope, strength, and progress.


Women’s Cancer Research Foundation (WCRF)


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