• Women's Cancer Research Foundation

Clinical Complications of Chemotherapy and Patient-Reported Outcomes After Breast Reconstruction



In a 2021 study published in the journal, JAMA, 1881 patients who received either implant-based or autologous (skin, fat, or muscle from the individual’s own body) breast reconstruction following neoadjuvant (before surgery) or adjuvant (after surgery) chemotherapy were assessed to determine their psychosocial outcomes.


All patients undergoing immediate implant-based or autologous reconstruction at 11 medical centers from January 2012 until December 2017, were included in the study analysis. The complications and patient-reported outcomes (satisfaction with breast and physical, psychosocial, and sexual well-being) were evaluated via the BREAST-Q questionnaire, a validated, condition-specific measure. On multivariable analysis, the psychosocial complications differences between implant-based and autologous breast reconstruction following both neoadjuvant and adjuvant chemotherapy were not statistically significant.


The psychosocial complications differences between implant-based and autologous breast reconstruction following both neoadjuvant and adjuvant chemotherapy were not statistically significant.

This information may assist patients and clinicians to make informed decisions regarding breast reconstruction in the setting of chemotherapy.


About Women’s Cancer Research Foundation The Women’s Cancer Research Foundation (WCRF) is one of Southern California’s and the nation’s most active research organizations for female cancers. We are dedicated to serving the interests of patients, families, and friends affected by women’s cancers. WCRF partners with physician-scientists nationally to make differences in women’s lives by offering hope, strength, and progress.


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